Reactive drug administration in Zanzibar

With low malaria prevalence in Zanzibar, malaria interventions have shifted from control to elimination practices. A previous study of reactive case detection – where council malaria surveillance officers test household members and surrounding households from a health facility index case – was implemented by Swiss Tropical Public Health Institute, Ifakara Health Institute, and Tulane University. This study showed that underlying infections were not detected by rapid test but were detectable by PCR, suggesting that a mass drug administration approach could better address the parasite reservoir that still exists among the Zanzibar population.

UCSF is collaborating with the Zanzibar Malaria Elimination Program and PMI Zanzibar to develop the methodology and standard operating procedures necessary to effectively implement reactive drug administration. The outputs of this activity will include guidelines for drug choice, guidelines for targeting of implementation, and recommended sites for small scale implementation of RDA in Zanzibar. The activity began in June 2022 and the guidelines will be available in October 2022.

Purpose:  Adapt the current standard operation procedures for rapid case detection to cover the new reactive drug administration intervention in Zanzibar.

Study team: UCSF

Timeline: June 2022 – October 2022